abstract：:Zinc is a basic trace element that plays important roles in brain and, consequently, its homeostasis needs to be critically controlled. High zinc concentrations in the interneuron synaptic space may induce neuronal death through mechanisms still partially solved. Undifferentiated pheochromocytoma (PC12) cells have bee...

journal_title：Brain research bulletin

authors： Sánchez-Martín FJ,Valera E,Casimiro I,Merino JM

更新日期：2010-03-16 00:00:00

abstract：:The chronic mild stress (CMS) model has been used as an animal model of depression which induces anhedonic behavior in rodents. The present study was aimed to evaluate the behavioral and physiological effects of administration of beta-carboline harmine in rats exposed to CMS procedure. To this aim, after 40 days of ex...

journal_title：Brain research bulletin

authors： Fortunato JJ,Réus GZ,Kirsch TR,Stringari RB,Fries GR,Kapczinski F,Hallak JE,Zuardi AW,Crippa JA,Quevedo J

更新日期：2010-03-16 00:00:00

abstract：:In the present study, cellular tropism and relative transduction efficiency of AAV2/6, AAV2/8 and AAV2/9 vectors have been tested for the cornea using primary cultures of human corneal fibroblasts. The AAV6, AAV8 and AAV9 serotypes having AAV2 ITR plasmid encoding for alkaline phosphatase (AP) gene were generated by t...

journal_title：Brain research bulletin

authors： Sharma A,Ghosh A,Hansen ET,Newman JM,Mohan RR

更新日期：2010-02-15 00:00:00

abstract：:An abundant recall of dreams has been observed in clinical studies on patients with narcolepsy-cataplexy (NC), a neurological disorder characterized by an altered sleep architecture. Laboratory studies have shown that dream experiences developed during 1st-rapid eye movement (REM) sleep by NC patients are longer and m...

journal_title：Brain research bulletin

authors： Mazzetti M,Bellucci C,Mattarozzi K,Plazzi G,Tuozzi G,Cipolli C

更新日期：2010-01-15 00:00:00

abstract：:Theories pertaining to the "why" of motion sickness are in short supply relative to those detailing the "how." Considering the profoundly disturbing and dysfunctional symptoms of motion sickness, it is difficult to conceive of why this condition is so strongly biologically based in humans and most other mammalian and ...

journal_title：Brain research bulletin

authors： Bowins B

更新日期：2010-01-15 00:00:00

abstract：:Sex differences are prominent influences on spatial performance. One of the most common tasks to assess sex differences in spatial navigation in rodents is the Morris water task (MWT). In this task rats swim in a pool of water to locate a hidden platform employing the topographical relationships among the distal visua...

journal_title：Brain research bulletin

authors： Faraji J,Metz GA,Sutherland RJ

更新日期：2010-01-15 00:00:00

abstract：:According to recently published papers acylated-ghrelin (A-Ghr) modifies memory and learning. The basolateral nucleus of amygdala (ABL) participates in the regulation of memory and learning mechanisms. Previously we verified A-Ghr responsive neurons in the ABL by electrophysiological methods. In male Wistar rats effec...

journal_title：Brain research bulletin

authors： Tóth K,László K,Lénárd L

更新日期：2010-01-15 00:00:00

abstract：:Transcription factor Pbx4 is recruited to form dimeric or trimeric complexes with Hox and/or Meis homeodomain proteins and participates in patterning the hindbrain and retina during vertebrate CNS development. We characterized a Pbx4 cDNA isolated from a Gekko japonicus brain and spinal cord cDNA library. Northern blo...

journal_title：Brain research bulletin

authors： Wang Y,Jiang X,Liu Y,Gu X,Huan Y,Ren L,Ding F,Gu X

更新日期：2009-12-16 00:00:00

abstract：:The neuropathology of Alzheimer disease is characterized by senile plaques, neurofibrillary tangles and cell death. These hallmarks develop according to the differential vulnerability of brain networks, senile plaques accumulating preferentially in the associative cortical areas and neurofibrillary tangles in the ento...

journal_title：Brain research bulletin

authors： Savioz A,Leuba G,Vallet PG,Walzer C

更新日期：2009-10-28 00:00:00

abstract：:Observation of people performing movements facilitates motor planning, execution and memory formation. Tempo, a crucial aspect involved in the execution of rhythmic movements, is normally perceived and learned through auditory channels. In this work, we ascertained whether: first, the frequency of self-paced finger mo...

journal_title：Brain research bulletin

authors： Bove M,Tacchino A,Pelosin E,Moisello C,Abbruzzese G,Ghilardi MF

更新日期：2009-09-28 00:00:00

abstract：:In this study we investigated the ability of the dentate gyrus to independently generate cholinergically induced theta rhythm in vitro. Two different experiments were performed. In Experiment I, new laminar profiles of theta phase, amplitude, and current sources and sinks were constructed. In this experiment a gradual...

journal_title：Brain research bulletin

authors： Kowalczyk T,Gołebiewski H,Konopacki J

更新日期：2009-09-28 00:00:00

abstract：:The claustrum is a relatively large telencephalic structure, situated close to the border of the neo- and allocortical regions. Its neuronal population consists of glutamatergic, projecting neurons and GABA-ergic interneurons, characterized by occurrence of numerous additional biochemical markers. The postnatal develo...

journal_title：Brain research bulletin

authors： Kowiański P,Dziewiatkowski J,Moryś JM,Majak K,Wójcik S,Edelstein LR,Lietzau G,Moryś J

更新日期：2009-09-28 00:00:00

abstract：:There is some experimental evidence that the pallial areas of a fish's brain are involved in distincted learning functions. Recently published data suggest that the medial pallium is essential for avoidance learning and the lateral pallium is crucial for spatial learning and is also involved in temporal aspects of the...

journal_title：Brain research bulletin

authors： Vargas JP,López JC,Portavella M

更新日期：2009-08-14 00:00:00

abstract：:Previous studies have shown that cognitive deficits precede the classical motor symptoms seen in Parkinson's disease (PD) and that physical exercise may exert beneficial effects on PD. We have recently verified that the monoamine-depleting drug reserpine - at doses that do not modify motor function - impairs memory pr...

journal_title：Brain research bulletin

authors： Aguiar AS Jr,Araújo AL,da-Cunha TR,Speck AE,Ignácio ZM,De-Mello N,Prediger RD

更新日期：2009-08-14 00:00:00

abstract：:In accordance with the genetic nature of Huntington's disease (HD), transgenic and knock-in mouse models have been developed that have sought to recapitulate the key features of the human condition. To date, only a single rat model has been developed, the tgHD rat that carries 51 CAG repeats. The tgHD rat has many of ...

journal_title：Brain research bulletin

authors： Brooks S,Fielding S,Döbrössy M,von Hörsten S,Dunnett S

更新日期：2009-06-30 00:00:00

abstract：:Several works have shown that males and females differ in the ability to learn spatial locations in mazes. In this study, we used the Morris water maze to assess the acquisition of a spatial working memory (WM) task in adult male and female Wistar rats. The task consisted of a paired sample procedure made up of two da...

journal_title：Brain research bulletin

authors： Méndez-López M,Méndez M,López L,Arias JL

更新日期：2009-05-29 00:00:00

abstract：:Early developmental abnormalities affecting mesocortical dopamine (DA) neurons may result in later functional deficits that play a role in the emergence of psychiatric illness in adolescence/early adulthood. Little is known about the functional maturation of these neurons under either normal or abnormal conditions. In...

journal_title：Brain research bulletin

authors： Boyce PJ,Finlay JM

更新日期：2009-04-29 00:00:00

abstract：:Deep hypothermic circulatory arrest in cardiothoracic surgery evokes severe brain damages. On the other hand, blood pressure stimuli discontinuation to the brain has been found to induce alterations in neurotransmitter release, including glutamate, in numerous brain regions. Furthermore, it is well established that ex...

journal_title：Brain research bulletin

authors： Kouvelas D,Amaniti E,Pourzitaki C,Kapoukranidou D,Thomareis O,Papazisis G,Vasilakos D

更新日期：2009-04-29 00:00:00

abstract：:The unique noradrenergic and specific serotonergic antidepressant mirtazapine acts antinociceptive. It is optically active and currently marketed as racemate. In an animal model of acute pain it has been shown that the enantiomers exhibit differential effects: the R(-)-enantiomer showed anti-, the S(+)-enantiomer pron...

journal_title：Brain research bulletin

authors： Muth-Selbach U,Hermanns H,Driehsen C,Lipfert P,Freynhagen R

更新日期：2009-04-06 00:00:00

abstract：:miR-196a is located in the posterior trunk and plays a role in limb development. Here we show that miR-196a is able to induce eye anomaly in Xenopus laevis. Microinjection of synthetic miRNA precursor molecule for mammalian miR-196a into Xenopus embryo is sufficient for miR-196a overexpression during early development...

journal_title：Brain research bulletin

authors： Qiu R,Liu Y,Wu JY,Liu K,Mo W,He R

更新日期：2009-04-06 00:00:00

abstract：:Electrical stimulation has been shown to have neuroprotective effects on ganglion cells and photoreceptors in axotomized and dystrophic retinas from Royal College of Surgeons (RCS) rats. This study determined whether electrical stimulation also has a neuroprotective effect on cells in the inner nuclear layer (INL) of ...

journal_title：Brain research bulletin

authors： Schmid H,Herrmann T,Kohler K,Stett A

更新日期：2009-04-06 00:00:00

abstract：:Locomotor performance of transgenic R6/2 mice carrying the Huntington's disease (HD) mutation was assessed using four different tasks, fixed speed rotarod, accelerating rotarod, Digigait and footprint test. The tasks were compared directly in age- and CAG repeat-matched R6/2 mice. Accelerating rotarod was more sensiti...

journal_title：Brain research bulletin

authors： Pallier PN,Drew CJ,Morton AJ

更新日期：2009-03-30 00:00:00

abstract：:Recent studies demonstrate that activation of Ca(2+)-permeable N-methyl-D-aspartate (NMDA) receptors upregulates phosphorylation of mitogen-activated protein kinases (MAPKs) in heterologous cells and neurons. In cultured rat striatal neurons, the present work systematically evaluated the role of a number of protein ki...

journal_title：Brain research bulletin

authors： Mao LM,Tang QS,Wang JQ

更新日期：2009-03-30 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, and is widely expressed in the adult mammalian brain. Besides its well known neuroprotective activity after traumatic brain injury the evidences regarding its activity dependent release by the pathophysiology of major depression ar...

journal_title：Brain research bulletin

authors： Yuluğ B,Ozan E,Gönül AS,Kilic E

更新日期：2009-03-30 00:00:00

abstract：:Fipronil, a GABA(A) receptor antagonist, is replacing many insecticide uses formerly fulfilled by organophosphates like chlorpyrifos. Few studies have addressed the potential for fipronil to produce developmental neurotoxicity. We compared the neurotoxicity of fipronil and chlorpyrifos in undifferentiated and differen...

journal_title：Brain research bulletin

authors： Lassiter TL,MacKillop EA,Ryde IT,Seidler FJ,Slotkin TA

更新日期：2009-03-30 00:00:00

abstract：:Brief cerebral ischemia leads to selective neuronal necrosis (SNN), which is characterized by neuronal death with sparing of glial and vascular elements of the central nervous system. Understanding the pathophysiology of SNN may help elucidating the mechanisms and consequences of neuronal injury in humans following br...

journal_title：Brain research bulletin

authors： Arsava EM,Gurer G,Gursoy-Ozdemir Y,Karatas H,Dalkara T

更新日期：2009-03-16 00:00:00

abstract：:After spinal cord injury (SCI) of the cat or rat neuronal centres below the level of lesion exhibit plasticity that can be exploited by specific training paradigms. In individuals with complete or incomplete SCI, human spinal locomotor centers can be activated by appropriate afferent input. This includes to facilitate...

journal_title：Brain research bulletin

authors： Dietz V

更新日期：2009-01-15 00:00:00

abstract：:Orexin/hypocretin neurons of the lateral hypothalamus/perifornical area project to a diverse array of brain regions and are responsive to a variety of psychostimulant drugs. It has been shown that orexin neurons are activated by systemic nicotine administration suggesting a possible orexinergic contribution to the eff...

journal_title：Brain research bulletin

authors： Pasumarthi RK,Fadel J

更新日期：2008-12-16 00:00:00

abstract：:Subcutaneous melittin injection causes central plasticity at the spinal level in wide-dynamic-range (WDR) neurons, which are hypersensitive to various nociceptive stimuli. Previous behavioral studies demonstrated that the mitogen-activated protein kinases (MAPKs) extracellular signal-regulated kinase 1/2(ERK1/2), p38 ...

journal_title：Brain research bulletin

authors： Li MM,Yu YQ,Fu H,Xie F,Xu LX,Chen J

更新日期：2008-11-25 00:00:00

abstract：:The gonadotrophin-releasing hormone 1 (GnRH1) system has been investigated immunohistochemically in Cape dune mole-rats (Bathyergus suillus), subterranean rodents that normally display severe aggression towards conspecifics. These animals breed seasonally and show a reduced mean plasma level of luteinising hormone dur...

journal_title：Brain research bulletin

authors： Hart L,Bennett NC,Kalamatianos T,Oosthuizen MK,Jarvis JU,O'Riain MJ,Coen CW

更新日期：2008-10-22 00:00:00

abstract：:Morphine exposure may have a negative effect on the receptive field properties of neurons in primary visual cortex of cats. The present experiment used morphological methods in order to investigate whether chronic morphine treatment also affects dendritic characters of these neurons. According to the Sholl analysis an...

journal_title：Brain research bulletin

authors： Hu F,Li G,Liang Z,Yang Y,Zhou Y

更新日期：2008-09-30 00:00:00

abstract：:Ghrelin (Ghr) has two main forms in the blood: the acylated (A-Ghr) and non-acylated (NA-Ghr) Ghr. A-Ghr was discovered as a potent growth hormone (GH) secretion increasing substance acting on GH secretagouge receptor (GHS-R) type 1a. A-Ghr facilitates food intake after its i.p., i.c.v. or direct hypothalamic applicat...

journal_title：Brain research bulletin

authors： Tóth K,László K,Bagi EE,Lukács E,Lénárd L

更新日期：2008-09-30 00:00:00

abstract：:The effects of the peptide transmitter neurotensin (NT) on the release of acetylcholine (ACh), gamma-aminobutyric acid (GABA), glutamate (Glu), aspartate (Asp), and taurine from the prefrontal cortex (PFC) of freely moving rats were studied by transversal microdialysis. Neurotensin (0.2 and 1 microM) administered loca...

journal_title：Brain research bulletin

authors： Petkova-Kirova P,Rakovska A,Della Corte L,Zaekova G,Radomirov R,Mayer A

更新日期：2008-09-30 00:00:00

abstract：:In this study, we compared the depression-like symptoms induced by olfactory bulbectomy (OBX) in the two inbred Wistar and Long Evans rat strains. We also analyzed the self-regulated oral intake of nicotine in these strains and the effect of nicotine on the depression-like symptoms of olfactory bulbectomy. Furthermore...

journal_title：Brain research bulletin

authors： Vieyra-Reyes P,Mineur YS,Picciotto MR,Túnez I,Vidaltamayo R,Drucker-Colín R

更新日期：2008-09-05 00:00:00

abstract：:Systemically administered human recombinant erythropoietin (EPO) may have the potential to reduce the cognitive and behavioural symptoms of mechanical brain injury. In a series of studies we address this possibility. Previously, we studied the effects of EPO given to fimbria-fornix transected rats at the moment of inj...

journal_title：Brain research bulletin

authors： Mogensen J,Boyd MH,Nielsen MD,Kristensen RS,Malá H

更新日期：2008-09-05 00:00:00

abstract：:The primary objective of this study was to determine whether pretreatment with kappa- and delta-opioid agonists potentiates naltrexone-induced suppression of water consumption following 24h of deprivation. This study also examined the temporal effects of agonist-induced antinociception using the tail-flick and hot-pla...

journal_title：Brain research bulletin

authors： White DA,Ballard ME,Harmon AC,Holtzman SG

更新日期：2008-08-15 00:00:00

abstract：:How deep brain stimulation (DBS) acts and how the brain responds to it remains unclear. To investigate the mechanisms involved, we analyzed changes in local field potentials from the subthalamic area (STN-LFPs) recorded through the deep brain macroelectrode during monopolar DBS of the subthalamic nucleus area (STN-DBS...

journal_title：Brain research bulletin

authors： Rossi L,Marceglia S,Foffani G,Cogiamanian F,Tamma F,Rampini P,Barbieri S,Bracchi F,Priori A

更新日期：2008-07-30 00:00:00

abstract：:The hypothalamic suprachiasmatic nucleus (SCN) and the thalamic intergeniculate leaflet (IGL) are considered to be the main centers of the mammalian circadian timing system. In primates, the IGL is included as part of the pregeniculate nucleus (PGN), a cell group located mediodorsally to the dorsal lateral geniculate ...

journal_title：Brain research bulletin

authors： Cavalcante JS,Britto LR,Toledo CA,Nascimento ES Jr,Lima RR,Pontes AL,Costa MS

更新日期：2008-07-01 00:00:00

abstract：:Serotonergic modulation of acetylcholine (ACh) release after neuron-specific increase of the expression of 5-HT(1B) receptors by gene transfer was studied in vitro and in vivo. The increased expression of the 5-HT(1B) receptor in vitro was induced by treating rat primary fetal septal cell cultures for 3 days with a vi...

journal_title：Brain research bulletin

authors： Riegert C,Rothmaier AK,Leemhuis J,Sexton TJ,Neumaier JF,Cassel JC,Jackisch R

更新日期：2008-07-01 00:00:00

abstract：:Subpallial structures are highly conserved across the different vertebrate species. They are instrumental in the neural processing relevant to adaptive learning, decision making, motivation and behavioural strategies. Of the striatal regions, our attention has been focussed on the medial and ventral striatum (MSt), no...

journal_title：Brain research bulletin

authors： Csillag A,Bálint E,Adám A,Zachar G

更新日期：2008-06-15 00:00:00